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Infection ; 49(1): 145-148, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-754159

ABSTRACT

A subset of patients with Covid-19 presents with negative RT-PCR screening but suspect CT findings. Using four commercially available anti-SARS-CoV-2 IgG immuno-assays, we found this subset constituted 9.2% of all consecutively admitted outpatients with Covid-19 in our hospital. Clinical specificity for Covid-19 of some N protein-based immuno-assays was suboptimal, as positive results were observed in control patients with recent common human coronavirus, influenza B and adenovirus infections.


Subject(s)
COVID-19 Testing/standards , COVID-19/diagnosis , Enzyme-Linked Immunosorbent Assay/statistics & numerical data , SARS-CoV-2/immunology , Adenovirus Infections, Human/diagnosis , Adenovirus Infections, Human/immunology , Adenovirus Infections, Human/virology , Adolescent , Adult , Aged , Aged, 80 and over , COVID-19/immunology , COVID-19/virology , Child , Child, Preschool , Coronavirus Infections/diagnosis , Coronavirus Infections/immunology , Coronavirus Infections/virology , Cross Reactions , False Positive Reactions , Female , Humans , Infant , Influenza, Human/diagnosis , Influenza, Human/immunology , Influenza, Human/virology , Male , Middle Aged , Reverse Transcriptase Polymerase Chain Reaction , SARS-CoV-2/genetics , Sensitivity and Specificity , Tomography, X-Ray Computed
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